• Participation in “Cells in Motion”

    • Research interests: cell-cell interactions, cell polarity, cell adhesion molecules, Junctional Adhesion Molecules (JAMs), integrins

  • Papers in the research focus “cell dynamics and imaging”

    2022

    Ebnet K, Gerke V. Rho and Rab Family Small GTPases in the Regulation of Membrane Polarity in Epithelial Cells. Front Cell Dev Biol 2022;10: 948013. Abstract
    Hartmann C, Thuring E-M, Greune L, Michels BE, Pajonczyk D, Leussink S, Brinkmann F, Glaesner-Ebnet M, Wardelmann E, Zobel T, Schmidt MA, Janssen K-P, Gerke V, Ebnet K. Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex. Sci Signal 2022;15: eabm2449. Abstract
    Kummer D, Steinbacher T, Tholmann S, Schwietzer MF, Hartmann C, Horenkamp S, Demuth S, Peddibhotla SSD, Brinkmann F, Kemper B, Schnekenburger J, Brandt M, Betz T, Liashkovich I, Kouzel IU, Shahin V, Corvaia N, Rottner K, Tarbashevich K, Raz E, Greune L, Schmidt MA, Gerke V, Ebnet K. A JAM-A-tetraspanin-alphavbeta5 integrin complex regulates contact inhibition of locomotion. J Cell Biol 2022;221Abstract
    Schwietzer MF, Tholmann S, Kummer D, Kaschler A, Greune L, Thuring E-M, Schmidt MA, Gerke V, Ebnet K. Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment. iScience 2022;25: 105144. Abstract
    Tholmann S, Seebach J, Otani T, Florin L, Schnittler H, Gerke V, Furuse M, Ebnet K. JAM-A interacts with alpha3beta1 integrin and tetraspanins CD151 and CD9 to regulate collective cell migration of polarized epithelial cells. Cell Mol Life Sci 2022;79: 88. Abstract

    2020

    Haas AJ, Zihni C, Ruppel A, Hartmann C, Ebnet K, Tada M, Balda MS, Matter K. Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly. Cell Rep 2020;32: 107924. Abstract
    Hartmann C, Schwietzer YA, Kummer D, Kirschnick N, Hoppe E, Thuring E-M, Glaesner-Ebnet M, Brinkmann F, Gerke V, Reuter S, Nakayama M, Ebnet K. The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria. BMC Mol Cell Biol 2020;21: 30. Abstract

    2019

    Otani T, Nguyen TP, Tokuda S, Sugihara K, Sugawara T, Furuse K, Miura T, Ebnet K, Furuse M. Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. J Cell Biol 2019;218: 3372-3396. Abstract

    2018

    Ebnet K, Kummer D, Steinbacher T, Singh A, Nakayama M, Matis M. Regulation of cell polarity by cell adhesion receptors. Semin Cell Dev Biol 2018;81: 2-12. Abstract
    Kummer D, Ebnet K. Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection. Cells 2018;7: E25. Abstract
    Steinbacher T, Ebnet K. The regulation of junctional actin dynamics by cell adhesion receptors. Histochem Cell Biol 2018;150: 341-350. Abstract
    Steinbacher T, Kummer D, Ebnet K. Junctional adhesion molecule-A: functional diversity through molecular promiscuity. Cell Mol Life Sci 2018;75: 1393-1409. Abstract

    2017

    Ebnet K. Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development. Physiol Rev 2017;97: 1529-1554. Abstract
    Ebnet K, Kummer D, Steinbacher T, Singh A, Nakayama M, Matis M. Regulation of cell polarity by cell adhesion receptors. Semin Cell Dev Biol 2017Abstract

    2016

    Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K. VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol Biol Cell 2016;27: 2811-2821. Abstract
    Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK, Bogdan S. Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. J Cell Biol 2016;212: 591-603. Abstract

    2015

    Tuncay H, Brinkmann BF, Steinbacher T, Schurmann A, Gerke V, Iden S, Ebnet K. JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun 2015;6: 8128. Abstract

    2013

    Peddibhotla SSD, Brinkmann BF, Kummer D, Tuncay H, Nakayama M, Adams RH, Gerke V, Ebnet K. Tetraspanin CD9 links junctional adhesion molecule-A to alphavbeta3 integrin to mediate basic fibroblast growth factor-specific angiogenic signaling. Mol Biol Cell 2013;24: 933-944. Abstract

    2012

    Iden S, Misselwitz S, Peddibhotla SSD, Tuncay H, Rehder D, Gerke V, Robenek H, Suzuki A, Ebnet K. aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation. J Cell Biol 2012;196: 623-639. Abstract