Publications
2024
Belga FN, Waindok P, Raulf MK, Jato J, Orman E, Rehbein S, Spiegler V, Liebau E, Hensel A, Ndjonka D, Strube C.Parasit Vectors. 2024 Mar 1;17(1):99. doi: 10.1186/s13071-024-06194-9.PMID: 38429804 Free PMC article.
https://pubmed.ncbi.nlm.nih.gov/38429804/François Ngnodandi Belga FN, Raulf MK, Spiegler V, Liebau E, Hensel A, Strube C, Ndjonka D. In vivo anthelmintic activity of Combretum mucronatum schumach & Thonn leaf extract against Haemonchus contortus in goats. Vet Parasitol. 2024 Oct;331:110288. doi: 10.1016/j.vetpar.2024.110288. Epub 2024 Aug 15. PMID: 39178741.
Jato J, Orman E, Boakye YD, Belga FN, Ndjonka D, Oppong Bekoe E, Liebau E, Spiegler V, Hensel A, Agyare C. Influence of fecal fermentation on the anthelmintic activity of proanthocyanidins and ellagitannins against human intestinal nematodes and Caenorhabditis elegans. Front Pharmacol. 2024 Jul 22;15:1390500. doi: 10.3389/fphar.2024.1390500. PMID: 39104390; PMCID: PMC11298482.
2023
Ahmad F, Liebau E, Rathaur S. Human immune response against filarial HSP70 and its role in the diagnosis of lymphatic filariasis, Parasite Immunol. 2023 Apr 18:e12978. doi: 10.1111/pim.12978. Online ahead of print. PMID: 370730922
Jato J, Orman E, Duah Boakye Y, Oppong Bekoe E, Oppong Bekoe S, Asare-Nkansah S, Spiegler V, Hensel A, Liebau E, Agyare C. Anthelmintic Agents from African Medicinal Plants: Review and Prospects, Evid Based Complement Alternat Med. 2022 Dec 31;2022:8023866. doi: 10.1155/2022/8023866. eCollection 2022. PMID: 36624864 Free PMC article. Review.
Jato J, Waindok P, Ngnodandi FNBF, Orman E, Agyare C, Bekoe EO, Strube C, Hensel A, Liebau E, Spiegler V. Anthelmintic Activities of Extract and Ellagitannins from Phyllanthus urinaria against Caenorhabditis elegans and Zoonotic or Animal Parasitic Nematodes. Planta Med. 2023 Oct;89(13):1215-1228. doi: 10.1055/a-2117-9426. Epub 2023 Jul 17. PMID: 37459860.
2022
Moustafa A, Perbandt M, Liebau E, Betzel C, Falke. Crystal structure of an extracellular superoxide dismutase from Onchocerca volvulus and implications for parasite-specific drug development, S. Acta Crystallogr F Struct Biol Commun. 2022 Jun 1;78(Pt 6):232-240. doi: 10.1107/S2053230X22005350. Epub 2022 May 27. PMID: 35647680
Greiffer L, Liebau E, Herrmann FC, Spiegler V. Condensed tannins act as anthelmintics by increasing the rigidity of the nematode cuticle, Sci Rep. 2022 Nov 7;12(1):18850. doi: 10.1038/s41598-022-23566-2. PMID: 36344622
2021
Sebastian Fuchs, Alexey G. Kikhney, Robin Schubert, Charlotte Kaiser, Eva Liebau, Dmitri I. Svergun, Christian Betzel, Markus Perbandt, Structure and dynamics of UBA5-UFM1 complex formation showing new insights in the UBA5 activation mechanism, Journal of Structural Biology, Volume 213, Issue 4, 2021, 107796, ISSN 1047-8477,
https://doi.org/10.1016/j.jsb.2021.107796Knetzger, N.; Bachtin, V.; Lehmann, S.; Hensel, A.; Liebau, E.; Herrmann, F. The Anthelmintic Quassinoids Ailanthone and Bruceine a Induce Infertility in the Model Organism Caenorhabditis elegans by an Apoptosis-Like Mechanism Induced in Gonadal and Spermathecal Tissues. Molecules 2021, 26, 7354.
https://doi.org/10.3390/molecules26237354Milena Lubisch, Sven Moyzio, Charlotte Sophia Kaiser, Isabel Krafeld, Dustin Leusder, Martin Scholz, Lara Hoepfner, Michael Hippler, Eva Liebau, Janina Kahl, Using Caenorhabditis elegans to produce functional secretory proteins of parasitic nematodes, Acta Trop. 2021 Oct 8;225:106176.
doi: 10.1016/j.actatropica.2021.106176
Murtadha L Al-Saady, Charlotte S Kaiser, Felipe Wakasuqui, G Christoph Korenke, Quinten Waisfisz, Abeltje Polstra, Petra J W Pouwels, Marianna Bugiani, Marjo S van der Knaap, Roelineke J Lunsing, Eva Liebau, Nicole I Wolf; Homozygous UBA5 Variant Leads to Hypomyelination with Thalamic Involvement and Axonal Neuropathy, Neuropediatrics. 2021 Apr 14. doi: 10.1055/s-0041-1724130, PMID: 33853163Ngwasiri NN, Brattig NW, Ndjonka D, Liebau E, Paguem A, Leusder D, Kingsley MT, Eisenbarth A, Renz A, Daniel AM; Galectins from Onchocerca ochengi and O. volvulus and their immune recognition by Wistar rats, Gudali zebu cattle and human hosts. BMC Microbiol. 2021 Jan 6;21(1):5. doi: 10.1186/s12866-020-02064-3.
2020
F. Valentin, H. Wiegmann, T. Tarinski, H. Nikolenko, H. Traupe, E. Liebau, M. Dathe, V. Oji. Development of a Pathogenesis-Based Therapy for Peeling Skin Syndrome Type 1. Br J Dermatol. 2020 Sep 14. doi: 10.1111/bjd.19546. Online ahead of print. PMID: 32926582
Fotoran WL, Kleiber N, Müntefering T, Liebau E, Wunderlich G. Production of glycosylphosphatidylinositol-anchored proteins for vaccines and directed binding of immunoliposomes to specific cell types. J. Venom. Anim. Toxins incl. Trop. Dis vol.26 Botucatu 2020 Epub Aug 03, 2020 doi: doi.org/10.1590/1678-9199-jvatitd-2020-0032
S Lehmann, F Herrmann, K Kleemann, V Spiegler, E Liebau, A Hensel. Extract and the Quassinoid Ailanthone From Ailanthus Altissima Inhibit Nematode Reproduction by Damaging Germ Cells and Rachis in the Model Organism Caenorhabditis elegans. Fitoterapia. 2020 Jun 3;146:104651. Online ahead of print. doi: 10.1016/j.fitote.2020.104651.
Bayat M, Tanny RE, Wang Y, Herden C, Daniel J, Andersen EC, Liebau E, Waschk DEJ. Effects of telomerase overexpression in the model organism Caenorhabditis elegans. Gene. 2020 Jan 16:144367. doi: 10.1016/j.gene.2020.144367
2019
Fotoran WL, Müntefering T, Kleiber N, Miranda BNM, Liebau E, Irvine DJ, Wunderlich G. A multilamellar nanoliposome stabilized by interlayer hydrogen bonds increases antimalarial drug efficacy. Nanomedicine. 2019 Nov;22:102099. doi: 10.1016/j.nano.2019.102099
Birmes FS, Säring R, Hauke MC, Ritzmann NH, Drees SL, Daniel J, Treffon J, Liebau E, Kahl BC, Fetzner S. Interference with Pseudomonas aeruginosa Quorum Sensing and Virulence by the Mycobacterial Pseudomonas Quinolone Signal Dioxygenase AqdC in Combination with the N-Acylhomoserine Lactone Lactonase QsdA. Infect Immun. 2019 Sep 19;87(10). doi: 10.1128/IAI.00278-19
Wiegmann H, Valentin F, Tarinski T, Liebau E, Loser K, Traupe H, Oji V. LEKTI domains 6, 7 and 8+9 serve as substrates for transglutaminase 1: implications for targeted therapy of Netherton syndrome. Br J Dermatol. 2019 Feb 22. doi: 10.1111/bjd.17820
2018
Kahl J, Brattig N, Liebau E. The Untapped Pharmacopeic Potential of Helminths.
Trends Parasitol. 2018 Oct;34(10):828-842. doi: 10.1016/j.pt.2018.05.011Ndjonka D, Djafsia B, Liebau E. Review on medicinal plants and natural compounds as anti-Onchocerca agents.
Parasitol Res. 2018 Sep;117(9):2697-2713. doi: 10.1007/s00436-018-6003-7Ditgen D, Anandarajah EM, Reinhardt A, Younis AE, Witt S, Hansmann J, Lorenz E, García-Hernández M, Paclik D, Soblik H, Jolodar A, Seeberger PH, Liebau E, Brattig NW. Comparative characterization of two galectins excreted-secreted from intestine-dwelling parasitic versus free-living females of the soil-transmitted nematode Strongyloides.
Mol Biochem Parasitol. 2018 Sep 1;225:73-83. doi: 10.1016/j.molbiopara.2018.08.008Boursou D, Ndjonka D, Eisenbarth A, Manchang K, Paguem A, Ngwasiri NN, Vildina JD, Abanda B, Krumkamp R, van Hoorn S, Renz A, Achukwi MD, Liebau E, Brattig NW. Onchocerca - infected cattle produce strong antibody responses to excretory-secretory proteins released from adult male Onchocerca ochengi worms.
BMC Infect Dis. 2018 May 2;18(1):200 doi: 10.1186/s12879-018-3109-6Mignon-Ravix C, Milh M, Kaiser CS, Daniel J, Riccardi F, Cacciagli P, Nagara M, Busa T, Liebau E, Villard L. Abnormal function of the UBA5 protein in a case of early developmental and epileptic encephalopathy with suppression-burst.
Hum Mutat. 2018 Apr 16. doi: 10.1002/humu.235342017
Spiegler V, Hensel A, Seggewiß J, Lubisch M, Liebau E. Transcriptome analysis reveals molecular anthelmintic effects of procyanidins in C. elegans.
PLoS One. 2017 Sep 19;12(9):e0184656 doi: 10.1371/journal.pone.0184656Kalmobé J, Ndjonka D, Boursou D, Vildina JD, Liebau E. Phytochemical analysis and in vitro anthelmintic activity of Lophira lanceolata (Ochnaceae) on the bovine parasite Onchocerca ochengi and on drug resistant strains of the free-living nematode Caenorhabditis elegans.
BMC Complement Altern Med. 2017 Aug 14;17(1):404. doi: 10.1186/s12906-017-1904-zSpiegler V, Liebau E, Hensel A. Medicinal plant extracts and plant-derived polyphenols with anthelmintic activity against intestinal nematodes
Nat Prod Rep. 2017 Jun 7;34(6):627-643. doi: 10.1039/c6np00126bDikti Vildina J, Kalmobe J, Djafsia B, Schmidt TJ, Liebau E, Ndjonka D. Anti-Onchocerca and Anti-Caenorhabditis Activity of a Hydro-Alcoholic Extract from the Fruits of Acacia nilotica and Some Proanthocyanidin Derivatives. Molecules. 2017 May 6;22(5). pii: E748. doi: 10.3390/molecules22050748
2016
Ditgen D, Anandarajah EM, Hansmann J, Winter D, Schramm G, Erttmann KD, Liebau E, Brattig NW. Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic Nematodes Strongyloides ratti and Trichuris suis Affects Mucosal Homeostasis. J Parasitol Res. 2016;2016:8421597.
Colin E, Daniel J, Ziegler A, Wakim J, Scrivo A, Haack TB, Khiati S, Denommé AS, Amati-Bonneau P, Charif M, Procaccio V, Reynier P, Aleck KA, Botto LD, Herper CL, Kaiser CS, Nabbout R, N'Guyen S, Mora-Lorca JA, Assmann B, Christ S, Meitinger T, Strom TM, Prokisch H; FREX Consortium., Miranda-Vizuete A, Hoffmann GF, Lenaers G, Bomont P, Liebau E, Bonneau D. Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy. Am J Hum Genet. 2016 Sep 1;99(3):695-703. doi: 10.1016/j.ajhg.2016.06.030.
Ajonina-Ekoti I, Ndjonka D, Tanyi MK, Wilbertz M, Younis AE, Boursou D, Kurosinski MA, Eberle R, Lüersen K, Perbandt M, Breloer M, Brattig NW, Liebau E. Corrigendum to "Functional characterization and immune recognition of the extracellular superoxide dismutase from the human pathogenic parasite Onchocerca volvulus (OvEC-SOD)" Acta Trop. 2016 Sep;161:114. doi: 10.1016/j.actatropica.2016.05.019.
Spiegler V, Liebau E, Peppler C, Raue K, Werne S, Strube C, Heckendorn F, Agyare C, Stark T, Hofmann T, Hensel A.A Hydroalcoholic Extract from Paullinia pinnata L. Roots Exerts Anthelmintic Activity against Free-Living and Parasitic Nematodes. Planta Med. 2016 Jun 10.
Anandarajah EM, Ditgen D, Hansmann J, Erttmann KD, Liebau E, Brattig NW. SPARC (secreted protein acidic and rich in cysteine) of the intestinal nematode Strongyloides ratti is involved in mucosa-associated parasite-host interaction. Mol Biochem Parasitol. 2016 Jun 3.
2015
Spiegler V, Sendker J, Petereit F, Liebau E, Hensel A. Bioassay-Guided Fractionation of a Leaf Extract from Combretum mucronatum with Anthelmintic Activity: Oligomeric Procyanidins as the Active Principle. Molecules. 2015 Aug 14;20(8):14810-32. doi: 10.3390/molecules200814810.
Perbandt M, Eberle R, Fischer-Riepe L, Cang H, Liebau E, Betzel C. High resolution structures of Plasmodium falciparum GST complexes provide novel insights into the dimer-tetramer transition and a novel ligand-binding site. J Struct Biol. 2015 Sep;191(3):365-75. doi: 10.1016/j.jsb.2015.06.008. Epub 2015 Jun 10.
Stegehake D, Kurosinski MA, Schürmann S, Daniel J, Lüersen K, Liebau E. Polyamine-independent Expression of Caenorhabditis elegans Antizyme. J Biol Chem. 2015 Jul 17;290(29):18090-101. doi: 10.1074/jbc.M115.644385. Epub 2015 Jun 1.
Valentin F, Oji V, Hausser I, Liebau E, Tarinski T, Metze D, Breitkreutz D, Traupe H, Jonca N, Terheyden P. Increased Expression of Caspase-1 and Interleukin-18 in Peeling Skin Disease, and a Novel Mutation of Corneodesmosin. Acta Derm Venereol. 2015 May 27.
Bosch SS, Kronenberger T, Meissner KA, Zimbres FM, Stegehake D, Izui NM, Schettert I, Liebau E, Wrenger C. (2015) Oxidative Stress Control by Apicomplexan Parasites. Biomed Res Int.
Manchang TK, Ajonina-Ekoti I, Ndjonka D, Eisenbarth A, Achukwi MD, Renz A, Brattig NW, Liebau E, Breloer M. May (2014) Immune recognition of Onchocerca volvulus proteins in the human host and animal models of onchocerciasis. J Helminthol.
Eberle R, Brattig NW, Trusch M, Schlüter H, Achukwi MD, Eisenbarth A, Renz A, Liebau E, Perbandt M, Betzel C. (2015) Isolation, identification and functional profile of excretory-secretory peptides from Onchocerca ochengi. Acta Trop. 2015 Feb
2014
Agyare C, Spiegler V, Sarkodie H, Asase A, Liebau E, Hensel A (2014) An ethnopharmacological survey and in vitro confirmation of the ethnopharmacological use of medicinal plants as anthelmintic remedies in the Ashanti region, in the central part of Ghana. J Ethnopharmacol. 2014 Dec 2;158 Pt A:255-63.
Ditgen D, Anandarajah EM, Meissner KA, Brattig N, Wrenger C, Liebau E. (2014) Harnessing the Helminth Secretome for Therapeutic Immunomodulators. Biomed Res Int. 2014:964350.
Kriegeskorte A, Block D, Drescher M, Windmüller N, Mellmann A, Baum C, Neumann C, Lorè NI, Bragonzi A, Liebau E, Hertel P, Seggewiss J, Becker K, Proctor RA, Peters G, Kahl BC. (2014) Inactivation of thyA in Staphylococcus aureus attenuates virulence and has a strong impact on metabolism and virulence gene expression.MBio. 5(4):e01447-14.
Daniel J, Liebau E. (2014) The ufm1 cascade. Cells. 3(2):627-38.
Hartmann W, Singh N, Rathaur S, Brenz Y, Liebau E, Fleischer B, Breloer M. Immunization with Brugia malayi Hsp70 protects mice against Litomosoides sigmodontis challenge infection. Parasite Immunol. 2014 Apr
Perbandt M, Ndjonka D, Liebau E. Protective mechanisms of helminths against reactive oxygen species are highly promising drug targets. Curr Med Chem. 2014
2013
Hartmann W, Singh N, Rathaur S, Brenz Y, Liebau E, Fleischer B, Breloer M. (2013) Immunization with Brugia malayi Hsp70 protects mice against Litomosoides sigmodontis challenge infection. Parasite Immunol. 2013 Dec 21.
Perbandt M, Ndjonka D, Liebau E.(2013) Protective Mechanisms of Helminths against Reactive Oxygen Species are Highly Promising Drug Targets. Curr Med Chem. 2013 Nov 19.
Wiebke Hartmann, Yannick Brenz, Manchang Tanyi Kingsley, Irene Ajonina-Ekoti, Norbert W. Brattig, Eva Liebau, Minka Breloer (2013) Nematode-Derived Proteins Suppress Proliferation and Cytokine Production of Antigen-Specific T Cells via Induction of Cell Death. PLOS ONE published 21 Jun.
Ajonina-Ekoti I, Kurosinski MA, Younis AE, Ndjonka D, Tanyi MK, Achukwi M, Eisenbarth A, Ajonina C, Lüersen K, Breloer M, Brattig NW, Liebau E. (2013) Comparative analysis of macrophage migration inhibitory factors (MIFs) from the parasitic nematode Onchocerca volvulus and the free-living nematode Caenorhabditis elegans. Parasitol Res. 2013 Jul 3.
Ndjonka D, Abladam ED, Djafsia B, Ajonina-Ekoti I, Achukwi MD, Liebau E (2013) Anthelminthic activity of phenolic acids from the axlewood tree Anogeissus leiocarpus on the filarial nematode Onchocerca ochengi and drug-resistant strains of the free-living nematode Caenorhabditis elegans. J Helminthol 17:1-8.
Kurosinski MA, Lüersen K, Ndjonka D, Younis AE, Brattig NW, Liebau E (2013). Filarial parasites possess an antizym but lack a functional ornithine decarboxylase. Acta Tropica. 126:167-76.
Lüersen K, Daniel J, Stegehake D, Drescher M, Ajonina I, Ajonina A, Hertel P, Woltersdorf C, Liebau E (2013). The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans. PLOS ONE. 8:e60731.
Hertel P, Daniel J, Stegehake D, Vaupel H, Kailayangiri S, Gruel C, Woltersdorf C, Liebau E. (2013) The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans. J. Biol. Chem. 288:10661-71.
Ndjonka D, Rapado LN, Silber AM, Liebau E, Wrenger C (2013) Natural products as a source for treating neglected parasitic diseases. International Journal of Molecular Sciences. 14:2295-439.
2012
Ajonina C, Buzie C, Ajonina IU, Basner A, Reinhardt H, Gulyas H, Liebau E, Otterpohl R. Occurrence of Cryptosporidium in a wastewater treatment plant in North Germany. J Toxicol Environ Health A. 2012;75(22-23):1351-8. doi: 10.1080/15287394.2012.721167
Ndjonka D, Ajonina-Ekoti I, Djafsia B, Lüersen K, Abladam E, Liebau E. Anogeissus leiocarpus extract on the parasite nematode Onchocerca ochengi and on drug resistant mutant strains of the free-living nematode Caenorhabditis elegans. Vet Parasitol. 2012 Nov 23;190(1-2):136-42. doi: 10.1016/j.vetpar.2012.05.027
Ajonina-Ekoti I, Ndjonka D, Tanyi MK, Wilbertz M, Younis AE, Boursou D, Kurosinski MA, Eberle R, Lüersen K, Perbandt M, Breloer M, Brattig NW, Liebau E. Functional characterization and immune recognition of the extracellular superoxide dismutase from the human pathogenic parasite Onchocerca volvulus (OvEC-SOD). Acta Trop. 2012 Oct;124(1):15-26. doi: 10.1016/j.actatropica.2012.05.013
Ndjonka D, Bergmann B, Agyare C, Zimbres FM, Lüersen K, Hensel A, Wrenger C, Liebau E. In vitro activity of extracts and isolated polyphenols from West African medicinal plants against Plasmodium falciparum. Parasitol Res. 2012 Aug;111(2):827-34. doi: 10.1007/s00436-012-2905-y
Younis AE, Soblik H, Ajonina-Ekoti I, Erttmann KD, Luersen K, Liebau E, Brattig NW. Characterization of a secreted macrophage migration inhibitory factor homologue of the parasitic nematode Strongyloides acting at the parasite-host cell interface. Microbes Infect. 2012 Mar;14(3):279-89. doi: 10.1016/j.micinf.2011.09.006Nouir NB, Eschbach ML, Piédavent M, Osterloh A, Kingsley MT, Erttmann K, Brattig N, Liebau E, Fleischer B, Breloer M. Vaccination with Strongyloides ratti heat shock protein 60 increases susceptibility to challenge infection by induction of Th1 response. Vaccine. 2012 Jan 20;30(5):862-71. doi: 10.1016/j.vaccine.2011.11.110
2011
Younis AE, Soblik H, Ajonina I, Erttmann KD, Luersen K, Liebau E, Brattig NW. (2011) Characterization of a secreted macrophage migration inhibitory factor homologue of the parasitic nematode Strongyloides acting at the parasite-host cell interface. Microbes Infect. 14:279-89.
Yadav M, Liebau E, Haldar C, Rathaur S. (2011) Identification of major antigenic peptide of filarial glutathione-S-transferase. Vaccine 29:1297-303.
Younis AE, Geisinger F, Ajonina-Ekoti I, Soblik H, Steen H, Mitreva M, Erttmann KD, Perbandt M, Liebau E, Brattig NW. (2011) Stage-specific excretory-secretory small heat shock proteins from the parasitic nematode Strongyloides ratti--putative links to host's intestinal mucosal defense system. FEBS J. 278:3319-36.