Publications
2021
Majstrowicz K, Honnert U, Nikolaus P, Schwarz V, Oeding SJ, Hemkemeyer SA, Bähler M.
Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19.
J Cell Sci. 2021 May 15;134(10):jcs255844. doi: 10.1242/jcs.255844.
Benfenati F, Bähler M, Valtorta F.
Giving names to the actors of synaptic transmission: The long journey from synaptic vesicles to neural plasticity.
Adv Pharmacol. 2021; 90:19-37. doi: 10.1016/bs.apha.2020.09.007. Epub 2021 Feb 26.2020
Hemkemeyer SA, Vollmer V, Schwarz V, Lohmann B, Honnert U, Taha M, Schnittler HJ, Bähler M.
Local Myo9b RhoGAP activity regulates cell motility.
J Biol Chem. 2020 Dec 2; 296: 100136. doi: 10.1074/jbc.RA120.013623.Hanley PJ, Vollmer V, Bähler M.
Class IX Myosins: Motorized RhoGAP Signaling Molecules.
Adv Exp Med Biol. 2020; 1239:381-389. doi: 10.1007/978-3-030-38062-5_16.2019
Horsthemke M, Nutter LMJ, Bachg AC, Skryabin BV, Honnert U, Zobel T, Bogdan S, Stoll M, Seidl MD, Mueller FU, Ravens U, Unger A, Linke WA, van Gorp PRR, de Vries AAF, Bähler M, Hanley PJ.
A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart.
J Biol Chem. 2019 Feb 8. pii: jbc.RA118.004560. doi: 10.1074/jbc.RA118.004560. [Epub ahead of print] Editors PickBachg AC, Horsthemke M, Skryabin BV, Klasen T, Nagelmann N, Faber C, Woodham E, Machesky LM, Bachg S, Stange R, Jeong HW, Adams RH, Bähler M, Hanley PJ.
Phenotypic analysis of Myo10 knockout (Myo10tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X.
Sci Rep. 2019 Jan 24;9(1):597. doi: 10.1038/s41598-018-37160-y.2018
Oeding SJ, Majstrowicz K, Hu XP, Schwarz V, Freitag A, Honnert U, Nikolaus P, Bähler M.
Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.
J Cell Sci. 2018 Sep 10;131(17). pii: jcs219469. doi: 10.1242/jcs.219469.Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck R, Balmer J, Fiocchi A, Kreutzfeldt M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV.
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells.
J Exp Med. 2018 Jul 2;215(7):1869-1890. doi: 10.1084/jem.20170896.Kim DG, Jeong YH, McMichael BK, Bähler M, Bodnyk K, Sedlar R, Lee BS.
Relationships of bone characteristics in MYO9B deficient femurs.
J Mech Behav Biomed Mater. 2018 Aug;84:99-107. doi: 10.1016/j.jmbbm.2018.05.003.2017
McMichael BK, Jeong YH, Auerbach JA, Han CM, Sedlar R, Shettigar V, Bähler M, Agarwal S, Kim DG, Lee BS.
The RhoGAP Myo9b Promotes Bone Growth by Mediating Osteoblastic Responsiveness to IGF-1.
J Bone Miner Res. 2017 Jun 6. doi: 10.1002/jbmr.3192. [Epub ahead of print]
Horsthemke M, Bachg AC, Groll K, Moyzio S, Müther B, Hemkemeyer SA, Wedlich-Söldner R, Sixt M, Tacke S, Bähler M, Hanley PJ.
Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion.
J Biol Chem. 2017 Apr 28;292(17):7258-7273. doi: 10.1074/jbc.M116.766923. Epub 2017 Mar 13.2016
Bzymek R, Horsthemke M, Isfort K, Mohr S, Tjaden K, Müller-Tidow C, Thomann M, Schwerdtle T, Bähler M, Schwab A, Hanley PJ. Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. Sci Rep. 2016 Apr 28;6:25016. doi: 10.1038/srep25016.
Hegan PS, Chandhoke SK, Barone C, Egan M, Bähler M, Mooseker MS. Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum. Cytoskeleton (Hoboken). 2016 Mar 12. doi: 10.1002/cm.21292. [Epub ahead of print]
Folci A, Murru L, Vezzoli E, Ponzoni L, Gerosa L, Moretto E, Longo F, Zapata J, Braida D, Pistillo F, Bähler M, Francolini M, Sala M, Bassani S.
Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function.
Front Mol Neurosci. 2016 Jan 20;9:1. doi: 10.3389/fnmol.2016.00001. eCollection 2016.2015
Thelen S, Abouhamed M, Ciarimboli G, Edemir B, Bähler M.The Rho GAP Myosin IXa is a regulator of kidney tubule function. Am. J. Physiol. Renal Physiol. 309(6):F501-13. doi: 10.1152/ajprenal.00220.2014
Liu Z, Xu Y, Zhang X, Song J, Sorokin L, Bähler MThe motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery. J. Neuroimmunol. 282 (2015): 25-32
doi:10.1016/j.jneuroim.2015.03.0142014
Königs V, Jennings R, Vogl T, Horsthemke M, Bachg AC, Xu Y, Grobe K, Brakebusch C, Schwab A, Bähler M, Knaus UG, Hanley PJ. Mouse Macrophages Completely Lacking Rho Subfamily GTPases (RhoA, RhoB, and RhoC) Have Severe Lamellipodial Retraction Defects, but Robust Chemotactic Navigation and Altered Motility. J Biol Chem. 2014 Oct 31;289(44):30772-84. doi: 10.1074/jbc.M114.563270. Epub 2014 Sep 11.
Elfrink K, Liao W, Pieper U, Oeding SJ, Bähler M. (2014) The loop2 insertion of type IX myosin acts as an electrostatic actin tether that permits processive movement. PLoS One. 2014 Jan 9;9(1):e84874. doi: 10.1371/journal.pone.0084874. eCollection 2014.
Xu Y*, Pektor S.*, Balkow S, Hemkemeyer SA, Liu Z, Grobe K, Hanley PJ, Shen L, Bros M, Schmidt T, Bähler M*, Grabbe S* (2014) Dendritic Cell Motility and T Cell Activation Requires Regulation of Rho-Cofilin Signaling by the Rho-GTPase Activating Protein Myosin IXb. J Immunol 192: 3559-3568. * joint first and last authors
2012 - 2009
2012
Hanley PJ, Kronlage M, Kirschning C, Del Rey A, Di Virgilio F, Leipziger J, Chessell IP, Sargin S, Filippov MA, Lindemann O, Mohr S, Königs V, Schillers H, Bähler M, Schwab A (2012) Transient P2X7 Receptor Activation Triggers Macrophage Death Independent of Toll-like Receptors 2 and 4, Caspase-1, and Pannexin-1 Proteins. J Biol Chem 287(13):10650-63.
2011
Weiser N., Molenda N., Urbanova K., Bähler M., Pieper U., Oberleithner H., Schillers H. (2011) Paracellular Permeability of Bronchial Epithelium is Controlled by CFTR. Cell Physiol Biochem 28:289-296.
Bähler M, Elfrink K, Hanley PJ, Thelen S, Xu Y. (2011) Cellular functions of class IX myosins in epithelia and immune cells. Biochem Soc Trans. 39(5):1166-8.
Isfort K, Ebert F, Bornhorst J, Sargin S, Kardakaris R, Pasparakis M, Bähler M, Schwerdtle T, Schwab A, and Hanley PJ (2011) Real-time Imaging Reveals That P2Y2 and P2Y12 Receptor Agonists Are Not Chemoattractants and Macrophage Chemotaxis to Complement C5a Is Phosphatidylinositol 3-Kinase (PI3K)- and p38 Mitogen-activated Protein Kinase (MAPK)-independent. J. Biol. Chem. 286: 44776-44787.
2010
Liao W, Elfrink K and Bähler M (2010) The head of myosin IX binds calmodulin and moves processively towards the plus-end of actin filaments. J. Biol. Chem. 285: 24933-24942.
Hanley PJ, Xu Y, Kronlage M, Grobe K, Schön P, Song J, Sorokin L, Schwab A, Bähler M. (2010) Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility. Proc Natl Acad Sci U S A. 107: 12145-12150.
Olety B, Wälte M, Honnert U, Schillers H, Bähler M. (2010) Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity. FEBS Lett. 584: 493-499.2009
Abouhamed M, Grobe K, San IV, Thelen S, Honnert U, Balda MS, Matter K, Bähler M. (2009) Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus. Mol Biol Cell. 20: 5074-5085.
Struchholz, S., Elfrink, K., Pieper, U., Kalhammer, G., Honnert, U., Grützner, A., Linke W., Liao, W., and Bähler, M. (2009) Functional role of the extended loop 2 in the myosin IXb head for binding F-actin. J. Biol. Chem. 284: 3663-3671.