Research Area 4 “Generic techniques”
All partners contribute their glyco-techniques to Research Area 4 “Generic techniques” to make the infrastructure and expertise of all MCGS groups available to all MCGS projects. Organic synthesis of oligosaccharides are performed by Balamurugan and Ramu Sridhar, while biosynthesis using enzymes is contributed by Appa Rao and Moerschbacher. The entire repertoire of classical carbohydrate analytical tools is available and continuously further developed in the Hensel group. Mass spectrometry of oligo- and polysaccharides pioneered by Peter-Katalinic is being further improved by Mormann, supported by Hippler and Moerschbacher. Physico-chemical techniques to analyse the solution properties of polysaccharides are applied by Goycoolea, who also contributes his expertise in nanobiotechnology, and to study carbohydrate-protein interactions by Swamy and Müthing. Lectins to be used as tools for both purification and characterization of glycans and glyco-conjugates are being studied in detail by Siva Kumar and Swamy. Bioassays to quantify biological activities of glycans are broadly contributed by Appa Rao, Götte, Goycoolea, Grobe, Hensel, Moerschbacher, Niyaz, Seidler, Suresh. Lalitha and Ulaganathan as well as Singh contribute their bioinformatic expertise. The one emerging crucial technology for analyzing carbohydrate-protein interactions which we are missing in our consortium due to the early exit of Bindila, are glyco-array technologies, for which we have made collaborative arrangements for the future with several leading experts from Academia (Feizi, Imperial College London; Seeberger, MPI Potsdam-Golm) and Industry (Weigle, scienion AG, Berlin).
Research projects in Research area 4.
| Dr. Mormann (Germany) |
Mass spectrometry of biologically active carbohydrates and their interactions with proteins more... |
| Prof. Dr. Hippler (Germany) |
We are interested in C. reinhardtii as a cell factory for the production of biopharmaceuticals. Therefore, information regarding its glycosylation capability is needed to support such applications. more... |
| Prof. Dr. Swamy (India) |
Research Projects. more... |
| Dr. Ulaganathan (India) |
Use of computational prediction and RNAi-based validation re-sulted in identification of the role of eight genes involved in this trait of upland rice. more... |
| Prof. Dr. Lalitha (India) |
We shall focus our studies to understand the structure function correlation of carbohydrate binding proteins and propose the necessary modification of proteins and/or substrates. more... |
| Dr. Balamurugan (India) |
Being a synthetic organic group, our aspiration and research focus pertaining to the MCGS pro-gramme is to synthesize chemical tools to understand the functions of carbohydrate binding pro-teins. more... |
| Dr. Ramu Sridhar (India) |
Current research projects more... |
Last update 06.26.2013
