Impact of plant and mammalian mucopolysaccharides on human keratinocytes and wound healing properties

In the last couple of years different therapies and wound pads were developed to improve wound healing. Several polysaccharides, like alginates have been established in wound healing products. The cell types involved in regeneration of the skin are fibroblasts and keratinocytes. An important role during the final progress in primary wound healing is the epithelialization. To improve these processes mucopolysaccharides derived from plants and mammalians are analyzed. Both polysaccharides improved proliferation of keratinocytes. The improvement of proliferation and differentiation of keratinocytes in the presence of mammalian glycosaminoglycans are also analyzed in a 3D in vitro cell culture model. The model is composed of skin fibroblasts in their own collagen-rich 3D matrix and keratinocytes seeded on top. This system has the advantage that the fibroblasts can provide the factors that are present under in vivo conditions.

Last update 18.06.2013

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