Functional characterization of Glypican heparan sulfate proteoglycans in Sonic hedgehog biology

Current advances

Ortmann/Grobe aim at the characterization of Glypican/HSPG functions in Shh release and activation in vitro and possibly in vivo. She has already cloned all six vertebrate glypicans for co-expression with Shh, followed by the analysis of their possibly differential processing and bioactivities of released morphogens. This will be done in collaboration with Götte, Swamy and Suresh.

Last update 18.04.2013

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