05.1998 – 06.1999

Postdoctoral Studies (biological mass spectrometry): Prof. Dr. J. Peter-Katalinic (Inst. f. Medizinische Physik und Biophysik); Centro Internationale di Servizi di Spettrometria di Massa (CISeSMa, Neapel, Consiglio Nationale delle Ricerche); Prof. Dr. Peter (Institut für Organische Chemie und Strukturanalytik der Universität Potsdam)

10.1994 – 02.1998

Ph. D. (H. J. Schäfer) WWU Münster: „Studien zur diastereselektiven Kupplung anodisch erzeugter Radikale in Hetero- und Homokupplungen“

10.1989 – 09.1994

Study of chemistry WWU Münster. Diploma (H. J. Schäfer) „Auxiliarkontrollierte Dimerisierung von 2-tert.-Butylmalonsäureamid- zu 2,3-Di-tert.-butylbernsteinsäurederivaten durch Kolbe-Elektrolyse“

since 07.2012

Head of mass spectrometry group at the Organisch-Chemischen Institut of the Westf. Wilhelms-Universität Münster

01. – 07.2012

Rep. head of mass spectrometry group at the Organisch-Chemischen Institut of the Westf. Wilhelms-Universität Münster

07.1999 – 12.2011

Head of mass spectrometry group (Universität Bielefeld, Fakultät für Chemie)

01.2017 – 12.2024

Treasurer and Board Member of the Deutsche Gesellschaft für Massenspektrometrie e.V. (Treasurer)

since 2005

Member of the ASMS - American Society for Mass Spectrometry

since 2004

Member of the DGMS - German Society for Mass Spectrometry

• 2023
• 2021
• 2020
• 2018
• 2017
• 2016
• 2015
• 2014
• 2013
• 2012
• 2011
• 2010
• 2009
• 2008
• 2007
• 2006
• 2005
• 2004
• 2003
• 2002
• 2001
• 2000
• 1995

2023

• Mo, Boris, Scharf, Birte, Gutheil, Christian, Letzel, Matthias C., and Hensel, Andreas. 2023. “Tamm-Horsfall protein in humane urine: sex-dependent differences in the excretion and N-glycosylation pattern.” Scientific Reports, № 13 (1) doi: 10.1038/s41598-023-44650-1.

2021

• Fraschetti, C., Letzel, M.C., Paletta, M., Mattay, J., Crestoni, M.E., Chiavarino, B., and Filippi, A. 2021. “Unprotected Galactosamine as a Dynamic Key for a Cyclochiral Lock.” Journal of The American Society for Mass Spectrometry, № 2021 (24): 736–743. doi: 10.1021/jasms.0c00437.

2020

• Watanabe, Kohei, Ueno, Atsushi, Tao, Xin, Skoch, Karel, Jie, Xiaoming, Vagin, Sergei, Rieger, Bernhard, Daniliuc, Constantin G., Letzel, Matthias C., Kehr, Gerald, and Erker, Gerhard. 2020. “Reactions of an anionic chelate phosphane/borata-alkene ligand with [Rh(nbd)Cl]2, [Rh(CO)2Cl]2and [Ir(cod)Cl]2.” Chemical science, № 11 (28) doi: 10.1039/d0sc02223c.
• Jansen, Dennis, Gramueller, Johannes, Niemeyer, Felix, Schaller, Torsten, Letzel, Matthias C., Grimme, Stefan, Zhu, Hui, Gschwind, Ruth M., and Niemeyer, Jochen. 2020. “What is the role of acid-acid interactions in asymmetric phosphoric acid organocatalysis? A detailed mechanistic study using interlocked and non-interlocked catalysts.” Chemical science, № 11 (17) doi: 10.1039/d0sc01026j.

2018

• Kuck, D., Heitkamp, S., Letzel, M., Ahmed, I., and Krohn, K. 2018. “Consecutive loss of two benzyl radicals from the [M + Na]+ adduct ions of pyrogallol tribenzyl ether and its derivatives.” European Journal of Mass Spectrometry, № 24 (1): 23–32. doi: 10.1177/1469066717729300.

2017

• Thierbach, Sven, Birmes, Franziska S., Letzel, Matthias C., Hennecke, Ulrich, and Fetzner, Susanne. 2017. “Chemical Modification and Detoxification of the <i>Pseudomonas</i> <i>aeruginosa</i> Toxin 2-Heptyl-4-hydroxyquinoline <i>N</i>-Oxide by Environmental and Pathogenic Bacteria.” ACS Chemical Biology, № 12 (9): 2305–2312. doi: 10.1021/acschembio.7b00345.
• Thierbach, S., Birmes, F., Letzel, M., Hennecke, U., and Fetzner, S. 2017. “Chemical Modification and Detoxification of the Pseudomonas aeruginosa Toxin 2-Heptyl-4-hydroxyquinoline N-Oxide by Environmental and Pathogenic Bacteria.” ACS Chemical Biology, № 12 (9): 2305–2312. doi: 10.1021/acschembio.7b00345.
• Tesch, M, Kudruk, S, Letzel, M, and Studer, A. 2017. “Orthogonal Click Postfunctionalization of Alternating Copolymers Prepared by Nitroxide-Mediated Polymerization.” Chemistry - A European Journal, № 23 (25): 5915–5919. doi: 10.1002/chem.201605639.
• Letzel, MC, Schäfer, H-J, and R, Fröhlich. 2017. “Diastereoselective anodic hetero- and homo-coupling of menthol-, 8-methylmenthol- and 8-phenylmenthol-2-alkylmalonates.” Beilstein Journal of Organic Chemistry, № 13 (null): 33–42. doi: 10.3762/bjoc.13.5.

2016

• Hickert, S., Cramer, B., Letzel, M., and Humpf, H.-U. 2016. “Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging of ochratoxin A and fumonisins in mold-infected food.” Rapid Communications in Mass Spectrometry, № 30 (23): 2508–2516. doi: 10.1002/rcm.7733.
• Elghamry, I., El-Ayaan, U., Youssef, M., Al-Shihry, S., Letzel, M., and Mattay, J. 2016. “Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products.” Chemical Monthly / Monatshefte für Chemie, № 2016: 1–6. doi: 10.1007/s00706-016-1765-z.
• Mitra, R., Thiele, M., Octa-Smolin, F., Letzel, M., and Niemeyer, J. 2016. “A bifunctional chiral [2]catenane based on 1,1′-binaphthyl-phosphates.” Chemical communications, № 52 (35): 5977–5980. doi: 10.1039/c6cc01980c.

2015

• Radunsky, C, Kösters, J, Letzel, MC, Yogendra, S, Schwickert, C, Manck, S, Sarkar, B, Pöttgen, R, Weigand, JJ, Neugebauer, J, and Müller, J. 2015. “Dioxygen Activation by an in situ Reduced Cu^II Hydrazone Complex.” European Journal of Inorganic Chemistry, № 2015: 4006–4012. doi: 10.1002/ejic.201500556.
• Volkenhoff, A., Weiler, A., Letzel, M., Stehling, M., Klämbt, C., and Schirmeier, S. 2015. “Glial glycolysis is essential for neuronal survival in drosophila.” Cell Metabolism, № 22 (3): 437–447. doi: 10.1016/j.cmet.2015.07.006.
• Tesch, M., Hepperle, J., Klaasen, H., Letzel, M., and Studer, A. 2015. “Alternating copolymerization by nitroxide-mediated polymerization and subsequent orthogonal functionalization.” Angewandte Chemie International Edition, № 54 (17): 5054–5059. doi: 10.1002/anie.201412206.
• Kuck, D., Heitkamp, S., Sproß, J., Letzel, M., Ahmed, I., Krohn, K., Parker, R., Wang, Y., Robbins, V., Ames, W., Schettler, P., and Hark, R. 2015. “Consecutive losses of two benzyl radicals from the [M+Na]⁺ adduct ions of di- and tri(benzyloxy)benzenes under ESI/CID conditions.” International Journal of Mass Spectrometry, № 377 (1): 23–38. doi: 10.1016/j.ijms.2014.06.013.

2014

• Kuck, D., Salameh, L., Onwuka, K., and Letzel, M. 2014. “Unidirectional triple hydrogen rearrangement in the radical cations of electron-rich 3-aryl-1-propanols: Further evidence and limitation.” European Journal of Mass Spectrometry, № 20 (1): 51–61. doi: 10.1255/ejms.1239.
• Pirkl, A., Meier, M., Popkova, Y., Letzel, M., Schnapp, A., Schiller, J., and Dreisewerd, K. 2014. “Analysis of free fatty acids by ultraviolet laser desorption ionization mass spectrometry using insect wings as hydrophobic sample substrates.” Analytical Chemistry, № 86 (21): 10763–10771. doi: 10.1021/ac5020047.

2013

• Letzel, M., Barth, D., Kuck, D., Grützmacher, H., Kim, S., Yim, M., and Choe, J. 2013. “Unimolecular reactions of gaseous picoline radical cations. A new experimental and computational study.” International Journal of Mass Spectrometry, № 336 (null): 1–16. doi: 10.1016/j.ijms.2012.11.005.
• Rozhenko, A., Schoeller, W., Letzel, M., Decker, B., and Mattay, J. 2013. “Anion-π interactions in adducts of anionic guests with octahydroxy-pyridine[4]arene: Theoretical and experimental elucidation.” New Journal of Chemistry, № 37 (2): 356–365. doi: 10.1039/c2nj40670e.

2012

• Amick, A., Hoegg, E., Harrison, S., Houston, K., Hark, R., Reingold, I., Barth, D., Letzel, M., and Kuck, D. 2012. “Site-specific hydrogen exchange and hydrogen transfer processes preceding the fragmentation of long-lived radical cations of ethyl dihydrocinnamate and related arylalkanoates.” International Journal of Mass Spectrometry, № null (null): 206–215. doi: 10.1016/j.ijms.2012.01.005.
• Fraschetti, C., Letzel, M., Paletta, M., Mattay, J., Speranza, M., Filippi, A., Aschi, M., and Rozhenko, A. 2012. “Cyclochiral resorcin[4]arenes as effective enantioselectors in the gas phase.” Journal of Mass Spectrometry, № 47 (1): 72–78. doi: 10.1002/jms.2028.
• Fraschetti, C., Letzel, M., Filippi, A., Speranza, M., and Mattay, J. 2012. “Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system.” Beilstein Journal of Organic Chemistry, № 8 (null): 539–550. doi: 10.3762/bjoc.8.62.

2011

• Botta, B., Fraschetti, C., D'Acquarica, I., Sacco, F., Mattay, J., Letzel, M., and Speranza, M. 2011. “Unprecedented gas-phase chiroselective logic gates.” Organic and Biomolecular Chemistry, № 9 (6): 1717–1719. doi: 10.1039/c0ob00664e.
• Kuck, D., Matthias, C., Barth, D., and Letzel, M. 2011. “Isomerization of the constituents of ion/neutral complexes during the fragmentation of protonated dialkyl-substituted 1,3-diphenylpropanes.” International Journal of Mass Spectrometry, № 306 (null): 167–174. doi: 10.1016/j.ijms.2010.10.007.
• Kuck, D., Grützmacher, H., Barth, D., Heitkamp, S., and Letzel, M. 2011. “The role of ion/neutral complexes in the fragmentation of N-benzyl-(alkylpyridinium) ions.” International Journal of Mass Spectrometry, № 306 (null): 159–166. doi: 10.1016/j.ijms.2010.10.006.

2010

• Krohn, K., Ahmed, I., John, M., Letzel, M., and Kuck, D. 2010. “Stereoselective synthesis of benzylated prodelphinidins and their diastereomers with use of the mitsunobu reaction in the preparation of their gallocatechin precursors.” European Journal of Organic Chemistry, № null (13): 2544–2554. doi: 10.1002/ejoc.201000053.

2009

• Botta, B., Fraschetti, C., D'Acquarica, I., Speranza, M., Novara, F., Mattay, J., and Letzel, M. 2009. “Gas-Phase enantioselectivity of chiral N-Linked peptidoresorc[4]arene isomers toward dipeptides.” Journal of Physical Chemistry A, № 113 (52): 14625–14629. doi: 10.1021/jp904374h.
• Böcker, S., Letzel, M., Lipták, Z., and Pervukhin, A. 2009. “SIRIUS: Decomposing isotope patterns for metabolite identification.” Bioinformatics, № 25 (2): 218–224. doi: 10.1093/bioinformatics/btn603.
• Botta, B., Fraschetti, C., Novara, F., Tafi, A., Sacco, F., Mannina, L., Sobolev, A., Mattay, J., Letzel, M., and Speranza, M. 2009. “Interactions of vinca alkaloid subunits with chiral amido[4]resorcinarenes: A dynamic, kinetic, and spectroscopic study.” Organic and Biomolecular Chemistry, № 7 (9): 1798–1806. doi: 10.1039/b900735k.
• Sekiguchi, O., Meyer, V., Letzel, M., Kuck, D., and Uggerud, E. 2009. “Energetics and reaction mechanisms for the competitive losses of H 2, CH4 and C2H4 from protonated methylbenzenes-implications to the methanol-to-hydrocarbons (MTH) process.” European Journal of Mass Spectrometry, № 15 (2): 167–181. doi: 10.1255/ejms.953.

2008

• Letzel, M.Grützmacher H., and Stein, D.Grützmacher H. 2008. “Trends in the reactions of gaseous phenyl pnictogen radical cations C 6H5EH2̇+ (E = N, P, As).” Dalton Transactions, № null (25): 3282–3291. doi: 10.1039/b801970c.
• König, H., Marsmann, H., and Letzel, M. 2008. “Thioether Functionalized Octasilsesquioxanes.” in Organosilicon Chemistry I: From Molecules to Materials, Vol. null , edited by Norbert Auner and Johann Weis. New York City: John Wiley & Sons. doi: 10.1002/9783527620777.ch69d.
• Igoli, J., Onyiriuka, S., Letzel, M., Nwaji, M., and Gray, A. 2008. “Cassane diterpenoids from Lonchocarpus laxiflorus.” Natural Product Communications, № 3 (1): 5–10.
• Schröder, T., Brodbeck, R., Letzel, M., Mix, A., Schnatwinkel, B., Tonigold, M., Volkmer, D., and Mattay, J. 2008. “A self-assembling metallosupramolecular cage based on cavitand-terpyridine subunits.” Tetrahedron Letters, № 49 (41): 5939–5942. doi: 10.1016/j.tetlet.2008.07.143.
• Letzel, M., Schäfer, C., Novara, F., Speranza, M., Rozhenko, A., Schoeller, W., and Mattay, J. 2008. “A kinetic study of guest displacement reactions on a host-guest complex with a photoswitchable calixarene.” Journal of Mass Spectrometry, № 43 (11): 1553–1564. doi: 10.1002/jms.1464.

2007

• Botta, B., D'Acquarica, I., Nevola, L., Sacco, F., Lopez, Z., Zappia, G., Fraschetti, C., Speranza, M., Tafi, A., Caporuscio, F., Letzel, M., and Mattay, J. 2007. “Bis(diamido)-bridged basket resorcin[4]arenes as enantioselective receptors for amino acids and amines.” European Journal of Organic Chemistry, № null (36): 5995–6002. doi: 10.1002/ejoc.200700829.

2006

• Schäfer, C., Decker, B., Letzel, M., Novara, F., Eckel, R., Ros, R., Anselmetti, D., and Mattay, J. 2006. “On the way to supramolecular photochemistry at the single-molecule level.” Pure and Applied Chemistry, № 78 (12): 2247–2259. doi: 10.1351/pac200678122247.
• Letzel, M., Kirchhoff, D., Grützmacher, H., Stein, D., and Grützmacher, H. 2006. “Isomerization and fragmentation reactions of gaseous phenylarsane radical cations and phenylarsanyl cations. A study by tandem mass spectrometry and theoretical calculations.” Dalton Transactions, № null (16): 2008–2016. doi: 10.1039/b514312h.
• Svelle, S., Bjørgen, M., Kolboe, S., Kuck, D., Letzel, M., Olsbye, U., Sekiguchi, O., and Uggerud, E. 2006. “Intermediates in the methanol-to-hydrocarbons (MTH) reaction: A gas phase study of the unimolecular reactivity of multiply methylated benzenium cations.” Catalysis Letters, № 109 (null): 25–35. doi: 10.1007/s10562-006-0052-8.
• Rozhenko, A., Schoeller, W., Letzel, M., Decker, B., Agena, C., and Mattay, J. 2006. “Calixarenes as hosts for ammonium cations: A quantum chemical study and mass-spectrometric investigations.” Chemistry - A European Journal, № 12 (35): 8995–9000. doi: 10.1002/chem.200501520.
• Böcker, S., Letzel, M., Lipták, Z., and Pervukhin, A. 2006. “Decomposing metabolomic isotope patterns.” in Vol. null of Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) Heidelberg: Springer.
• Sekiguchi, O., Letzel, M., Kuck, D., and Uggerud, E. 2006. “The unimolecular dissociation of protonated glyoxylic acid: Structure and dynamics of a step-by-step process.” International Journal of Mass Spectrometry, № null (null): 177–184. doi: 10.1016/j.ijms.2005.12.041.

2005

• Schulte, T, Siegenthaler, KO, Luftmann, H, Letzel, M, and Studer, A. 2005. “Nitroxide-mediated polymerization of N-isopropylacrylamide: Electrospray ionization mass spectrometry, matrix-assisted laser desorption ionization mass spectrometry, and multiple-angle laser light scattering studies on nitroxide-terminated poly-N-isopropylacrylamides.” Macromolecules, № 38 (16): 6833–6840. doi: 10.1021/ma050343n.
• Rozhenko, A., Schoeller, W., Letzel, M., Decker, B., Agena, C., and Mattay, J. 2005. “Conformational features of calix[4]arenes with alkali metal cations: A quantum chemical investigation with density functional theory.” Journal of Molecular Structure: THEOCHEM, № 732 (null): 7–20. doi: 10.1016/j.theochem.2005.06.041.

2004

• Mehdizadeh, A., Letzel, M., Klaes, M., Agena, C., and Mattay, J. 2004. “Chiral discrimination on the host-guest complexation of resorc[4]arenes with quarternary amines.” European Journal of Mass Spectrometry, № 10 (5): 649–655. doi: 10.1255/ejms.675.
• Oley, M., Letzel, M., and Ragg, H. 2004. “Inhibition of furin by serpin Spn4A from Drosophila melanogaster.” FEBS Letters, № 577 (null): 165–169. doi: 10.1016/j.febslet.2004.10.003.
• Letzel, M., Decker, B., Rozhenko, A., Schoeller, W., and Mattay, J. 2004. “Encapsulated guest molecules in the dimer of octahydroxypyridine[4]arene.” Journal of the American Chemical Society, № 126 (31): 9669–9674. doi: 10.1021/ja049128x.

2003

• Leitão, E., Bittencourt, V., Haido, R., Valente, A., Peter-Katalinic, J., Letzel, M., de, Souza L., and Barreto-Bergter, E. 2003. “β-Galactofuranose-containing O-linked oligosaccharides present in the cell wall peptidogalactomannan of Aspergillus fumigatus contain immunodominant epitopes.” Glycobiology, № 13 (10): 681–692. doi: 10.1093/glycob/cwg089.

2002

• Bahrke, S., Einarsson, J., Gislason, J., Haebel, S., Letzel, M., Peter-Katalinić, J., and Peter, M. 2002. “Sequence analysis of chitooligosaccharides by matrix-assisted laser desorption ionization postsource decay mass spectrometry.” Biomacromolecules, № 3 (4): 696–704. doi: 10.1021/bm020010n.
• Müller, A., Diemann, E., Shah, S., Kuhlmann, C., and Letzel, M. 2002. “Soccer-playing metal oxide giant spheres: A first step towards patterning structurally well defined nano-object collectives.” Chemical communications, № null (5): 440–441.
• Letzel, M., Agena, C., and Mattay, J. 2002. “Investigation of homo- and heterodimer alkali metal cation complexes of resorc[4]arenes by electrospray ionization mass spectrometry.” Journal of Mass Spectrometry, № 37 (1): 63–68. doi: 10.1002/jms.247.
• Letzel, M., Grützmacher, H., Fürst, T., Mayer, K., and Wiegrebe, W. 2002. “Functional group migration in benzaldoxime-O-n-propyl ether radical cation.” International Journal of Mass Spectrometry, № 217 (null): 153–168. doi: 10.1016/S1387-3806(02)00571-7.

2001

• Hollah, P, Hausberg, M, Kosch, M, Barenbrock, M, Letzel, M, Schlatter, E, and Rahn, KH. 2001. “A novel assay for determination of diadenosine polyphosphates in human platelets: studies in normotensive subjects and in patients with essential hypertension.” Journal of Hypertension, № 19 (2): 237–245. doi: 10.1097/00004872-200102000-00010.
• Letzel, M., Agena, C., and Mattay, J. 2001. “Letter: Calibration of electrospray mass spectrometers with rccc-2,8,14,20-tetra-n-octyl-5,11,17,23- tetrahydroxyresorc[4]arene in the high mass range up to m/z 6000.” European Journal of Mass Spectrometry, № 7 (1): 35–38.

2000

• Letzel, Matthias C., Synstad, B., Eijsink, V.G.H, Peter-Katalinić, Jasna, and Peter, Martin G. 2000. “Libraries of chito-oligosaccharides of mixed acetylation patterns and their interactions with chitinases.” in Advan. Chitin Science 2000, Vol. IV, edited by G. Peter, R.A.A. Muzzarelli and A. Domard. N/A: unbekannt / n.a. / unknown.

1995

• Schäfer, H.J., Klotz-Berendes, B., Letzel, M., Zielinski, C., Schoo, N., and Lohl, T. Höweler U. 1995. “Diastereoselective and Enantioselective Conversions at the Anode and the Cathode.” in Novel Trends in Electroorganic Synthesis, edited by Torii Sigeru. Okayama.